The prognosis of primary disseminated multifocal metastatic Ewing's sarcoma (PDMES) is poor even if a slight improvement has been achieved with high-dose alkylating agent-containing chemotherapy. To enhance treatment efficacy, we assessed the feasibility, safety and efficacy of a tandem high-dose chemotherapy (HDC) regimen.

Authors: S. Loschi, C. Dufour, O. Oberlin, G. Goma, D. Valteau-Couanet, N. Gaspar.

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