It can be difficult to explain pediatric phase 1 oncology trials to families of children with refractory cancer. Parents may misunderstand the information presented to them, and physicians may assume that certain topics are covered in the informed consent document and need not be discussed. Communication models can help to ensure effective discussions.

Authors: Liza-Marie Johnson, Angela C. Leek, Dennis Drotar, Robert B. Noll, Susan R. Rheingold, Eric D. Kodish, and Justin N. Baker

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